Synthesis and antifungal evaluation of some novel benzopyridazines

A series of some new 1-(substituted thioanilido)-8-Keto-3-substituted benzopyridazines (III) were prepared by reacting 4-aryl-3-thiosemicarbazides (I) with 2-carboxyl-(substituted benzophenones). Thiosemicarbazones(II), so formed on cyclodehydration gave the titled compounds. These benzopyridazines were screened for their antifungal activities. Based on the screening data, some structure activity relationship was established .