Studies on LSF technique for the bioproduction of H3Cit exposed to carbamate mutagen

Sodium diethyl dithiocarbamate (SDDC) is a chemical compound with various applications. Carbamate compounds can have various biological effects, including potential, mutagenicity. Certain carbamates may cause genetic mutations. Research focuses on understanding the mechanism of carbamate induced mutagenicity and carcinogenecity. Carbamate mutagens could potentially alter the genetic makeup of microorganisms used in citric acid fermentation by Aspergillus niger. Mutations induced by carbamates might affect the microorganisms ability to produce citric acid, potentially altering fermentation efficiency or product yield. Researcher might investigate the use of carbamate mutagenes to induce mutations that enhances citric acid production or improve fermentation efficiency.In the pressent communication the impact of carbamate mutagen, i.e., sodium diethyl dithiocarbamate (SDDC) on LSF technique for the bioproduction of H3Cit by fungal strains of Aspergillus wentii SS-63, Aspergillus carbonarius SS65, Aspergillus foetidus SS-67 and Aspergillus niger SS- 69 has been assessed for their H3Cit producing capacity. It has been found that fungal strain of Aspergillus niger SS-69 has been found most affective and significant as H3Cit producer. It has been found that the carbamate mutagen, i.e., SDDC has stimulative impact on bioproduction of H3Cit by Aspergillus niger SS-69 and enhances the yield of H3Cit to an extent of 20.416 % higher in comparison to control fermentation flask, i.e., 9.375gm/100ml under optimised parameters.